Light-Induced Function

Light-Induced Function

#LIFETimeS #WebSite
From Excitation to Signal

From Excitation to Signal

#LIFETimeS #website
Through Time and Space

Through Time and Space

#LIFETimeS #WebSite
Light-Induced Function

Light-Induced Function

#LIFETimeS #WebSite
From Excitation to Signal

From Excitation to Signal

#LIFETimeS #WebSite
Through Time and Space

Through Time and Space

#LIFETimeS #WebSite

New Article in The Journal of Physical Chemistry

New Article in The Journal of Physical Chemistry

Ultrafast transient infrared spectroscopy is a powerful technique that not only indicates the dynamic structural changes of protein-bound chromophores involved in a photochemical reaction but also reveals the implications of...

Excited States of Xanthophylls Revisited: Toward the Simulation of Biologically Relevant Systems

Excited States of Xanthophylls Revisited: Toward the Simulation of Biologically Relevant Systems

Xanthophylls are a class of oxygen-containing carotenoids, which play a fundamental role in light-harvesting pigment−protein complexes and in many photoresponsive proteins. The complexity of the manifold of the electronic states...

New review on Annual Review of Physical Chemistry

New review on Annual Review of Physical Chemistry

Multiscale models combining quantum mechanical and classical descriptions are a very popular strategy to simulate properties and processes of complex systems. Many alternative formulations have been developed, and they are...

 

LIFETimes
Light-Induced Function: from Excitation to Signal through Time and Space
ERC-2017-ADG (n. 786714)

erc logoOrganisms of all domains of life are capable of sensing, using and responding to light. The molecular mechanisms used are diverse, but most commonly the starting event is an electronic excitation localized on a chromophoric unit bound to a protein matrix. The initial excitation rapidly “travels” across space to be converted in other forms of energy and finally used to complete the biological function. The whole machinery spans many different space and time scales: from the ultrafast electronic process localized at the subnanoscale of the chromophoric units, through conformational processes which involve large parts of the protein and are completed within micro- to milli-seconds, up to the activation of new protein-protein interactions requiring seconds or more. Theoretically addressing this cascade of processes calls for new models and computational strategies able to reproduce the dynamics across multiple space and time scales. Such a goal is formidably challenging as the interactions and the dynamics involved at each scale follow completely different laws, from those of the quantum world to those of classical particles. Only a strategy based upon the integration of quantum chemistry, classical atomistic and coarse-grained models up to continuum approximations, can achieve the required completeness of description. This project aims at developing such integration and transforming it into high-performance computing codes. The completeness and accuracy reached by the simulations will represent a breakthrough in our understanding of the mechanisms, which govern the light-driven bioactivity. Through this novel point of observation of the action from the “inside”, it will be possible not only to reveal the ‘design principles’ used by Nature but also to give a “practical” instrument to test “in silico” new techniques for the control of cellular processes by manipulating protein functions through light.


LIFETimeS page on OpenAIRE
logo large explore

https://explore.openaire.eu/search/project?projectId=corda__h2020::034d86772f0aa47ce92c3c8aeb33c481

NEW VIDEO: LHCII

NEW VIDEO: LH2 hq

LifeTimes
Dipartimento di Chimica e Chimica Industriale
Via Giuseppe Moruzzi, 13
56124 - Pisa, Italy
● ● ●
lifetimes.dcci.unipi.it
Powered by Dcci-Unipi
Privacy Policy

eucomm
This project has received funding from the European Research Council (ERC) 
under the Horizon 2020 research and innovation programme
(Grant agreement No. 786714)